A report by NSW motoring body NRMA Motoring & Services shows that almost 50 percent of the state's Oxley Highway poses a major risk to motorists.
The report, which analysed crash and traffic data over two five year periods, shows that the state of the highway has only worsened in the past decade.
According to the report, ongoing neglect of maintenance has led to an increase in fatal crashes by 70 percent between 2000-04 and 2005-09.
"We received a lot of complaints about the Oxley Highway during our Seeing Red on Roads campaign," NRMA Motoring & Services Director Graham Blight said.
"Motorists complained of a lot of pot holes heading out of Tamworth in both directions, a lack of overtaking lanes across the length of the road and narrow, windy sections heading over the Great Dividing Range."
The most dangerous section of the Oxley Highway is the section between Walcha and Bendemeer, which the report described as a "high risk" area.
The 161km stretch between Walcha and Wauchope has seen the sharpest increase in crashes resulting in casualties (death or injury), up 25 percent between 2000-04 and 2005-09.